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KMID : 1098420090170010054
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Korean Journal of Medicinal Crop Science
2009 Volume.17 No. 1 p.54 ~ p.60
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Enhancement of Immuno Modulatory Activities of Rubus coreanus Miquel Extracts by Nano-encapsulation Process
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Han Jae-Gun
Kwon Min-Cheol
Ha Ji-Hye
Jeong Hyang-Suk
Kim Young
Jeong Myeong-Hoon
Kim Jin-Chul
Lee Hyeon-Yong
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Abstract
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This study was performed to improve immune activities of Rubus coreanus Miquel by encapsulation of nanoparticles.
Immuno-activities of R. coreanus were investigated through aqueous extracts associated with process of water at 60℃. It showed high promotion of human B and T cells growth about 50%, compared to the case of other conditions. The secretion of IL-6 and TNF-α was also enhanced as 2.44 × 10?4 pg/cell and 1.94 × 10?4 pg/cell, results by adding nano samples. NK cell activation was improved up to 29% higher than the conventional extraction process. The secretion of NO from macrophage showed 14.9 μM on the nano-encapsulation process extracts, which was higher than others. The size of nanoparticles was in the range of 50~300㎚, which can effect the penetration into the cells. It was clearly observed by real time confocal microscope.
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KEYWORD
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Rubus coreanus Miquel, Eatable Nano-Encapsulation, Immuno modulatory Activities
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